THE XENOPUS TOAD TEST FOR THE DIAGNOSIS OF PREGNANCY

BELLERBY, C. W. LANCELOT.

A Rapid Test for the Diagnosis of Pragnancy.

London, Macmillan & Co., 1934. Royal8vo. In the original printed wrappers. In "Nature", No. 3361, Vol. 133, March, 1934. Entire issue offered. A very fine and clean copy. Pp. 494-5. [Entire issue: Pp. XCVIII-C, 473-508, CI-CIV].

First appearance of Bellerby's semnial paper interoducing the first reliable pregnancy test: The Xenopus tead pregnancy text

Hogben had in 1930 demonstrated that that if the Xenopus toad was injected with anterior pituitary preparations ovulation and oviposition could be induced. Bellerby in 1933 showed that
if instead of keeping the frogs in a cold underground room, he housed them in warm and well lit surroundings he could eliminate the 'captivity effect' and achieve reliability of testing close to 100%. With the minimized captivity effect Bellerby showed that this phenomenon could be utilized as a pregnancy test.

"The Xenopus toad test for the diagnosis of pregnancy; this preliminary note followed Hogben's demonstration that Xenopus responds by ovulation to the gonadotrophic hormone" (Garrison & Morton 6226).

Garrison & Morton 6226

Order-nr.: 48624